Nathaniel Marchetti, DO, Professor of Thoracic Medicine and Surgery at the Lewis Katz School of Medicine at Temple University and Medical Director of the Respiratory Intensive Care Unit at Temple University Hospital, provided perspective for an MDedge article on a Danish population-cohort study published in the Annals of Allergy, Asthma and Immunology which found that patients with COPD (chronic obstructive pulmonary disease) with high plasma immunoglobulin E (IgE) are more likely to have exacerbations and die from any cause. Dr. Marchetti was not involved in the study.