A HemOnc Today article on findings published in JAMA Otolaryngology Head and Neck Surgery on circulating tumor tissue-modified viral HPV DNA featured comments from an accompanying editorial by Jeffrey C. Liu, MD, FACS, Associate Professor of Otolaryngology – Head & Neck Surgery at the Lewis Katz School of Medicine at Temple University, Director of Head and Neck Oncologic Surgery at Temple University Hospital and Attending Surgeon at Fox Chase Cancer Center.