Media Outlet Highlights New Research from Lewis Katz School of Medicine Scientists on Reintroduction of LIN28 Protein into Stem Cells Derived from Adult Heart Tissue

To augment heart repair after ischemic injury, researchers have turned to stem cell-based therapies, which replace dead heart tissue with new, functional tissue. In most cases, however, fewer than 1 percent of stem cells survive transplantation into the heart. In new research, scientists at the Lewis Katz School of Medicine at Temple University show that, in mice, this obstacle can be overcome through the reintroduction of LIN28 – a protein normally expressed in the developing heart – into stem cells derived from adult heart tissue. The new findings were published online in the journal Redox Biology. Mohsin Khan, PhD, Assistant Professor of Cardiovascular Sciences at the Cardiovascular Research Center at the Katz School of Medicine, is the senior investigator on the new study. Medical Xpress highlighted the research.