Researchers at the Lewis Katz School of Medicine at Temple University (LKSOM) have shown in two new studies that in the heart, the molecule Krüppel-like factor (KLF)-5 single-handedly fuels the generation of oxidizing molecules and the accumulation of toxic lipids known as ceramides, exacerbating heart dysfunction. The studies, published in the journals Circulation and Circulation Research, are the first to identify KLF5 as a common mediator of cardiac damage in animal models of different diseases that lead to abnormal heart function, including diabetes and heart attack. The studies were led by Konstantinos Drosatos, PhD, Associate Professor of Pharmacology at the Center for Translational Medicine, the Center for Metabolic Disease Research and the Alzheimer’s Center at Temple at LKSOM, as well as additional colleagues. Media outlets, including Medical Xpress, Scienmag, News-Medical.net, Technology Networks and others, covered the news.
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