The Academic Times interviewed Walter J. Koch, PhD, W.W. Smith Endowed Chair in Cardiovascular Medicine, Professor and Chair of the Department of Pharmacology and Director of the Center for Translational Medicine at the Lewis Katz School of Medicine at Temple University, about recent research published online in the journal Science Signaling that showed for the first time in animals that keeping a signaling protein known as G protein-coupled kinase 5 (GRK5) out of the heart cell nucleus can block maladaptive growth of the heart. The findings open avenues for the development of GRK5-based therapies to prevent heart failure. Dr. Koch is the senior investigator on the study, and Dr. Ryan C. Coleman, a former graduate student in the Koch laboratory, is first author on the report.
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